With a rising prevalence and high rates of morbidity and mortality, heart failure has become a prominent personal and public health burden. Recently, Veradigm® published a whitepaper that described heart failure with reduced ejection fraction (HFrEF), also known as systolic heart failure, and characterized ambulatory patients with HFrEF using de identified real-world data from an EHR platform Practice Fusion, a Veradigm offering. That paper briefly touched on another type of heart failure, heart failure with preserved ejection fraction (HFpEF), also referred to as diastolic heart failure. Despite similarities in clinical expression, HFrEF and HFpEF differ in their etiologies, cardiac remodeling patterns, biomarker profiles, and responsiveness to pharmacotherapy. This paper addresses HFpEF, with a focus on major comorbidities and on two classes of emerging pharmacotherapies. A retrospective data review using de-identified patient data from the EHR Practice Fusion demonstrates how real world evidence may be leveraged to offer insights regarding HFpEF.